Fracture-related infection (FRI) remains one of the most challenging complications in orthopaedic trauma, often leading to bone destruction, implant failure, and prolonged treatment. This project (DONUT – Development of advanced Osteolysis Model drive by NeUTrophils) aims to advance knowledge by developing a novel human-relevant 3D in vitro model that integrates spatially organized bone constructs generated using Sound-Induced Morphogenesis, immune cell populations including neutrophils, controlled introduction of Staphylococcus aureus, and advanced molecular and imaging-based readouts. The project will provide mechanistic insights into infection-induced osteolysis and a platform for testing new therapeutic strategies.
Tasks
- Develop and optimise 3D biofabricated bone model with immune cells
- Establish infection models with Staphylococcus aureus
- Introduce and study neutrophil-driven inflammatory processes
- Apply advanced analytical techniques (e.g. imaging, transcriptomics, cytokine profiling)
- Analyse and interpret experimental data
- Contribute to scientific publications and presentations
Requirements
- Master’s degree in biomedical engineering, biology, microbiology, or a related field
- Experience in cell culture and laboratory techniques (e.g. molecular biology, microscopy, microbiology)
- Experience in neutrophil handling and culture
- Experience in planning and executing research experiments
- Strong interest in infection biology, immunology, and/or biomaterials
- Excellent communication skills in English
- Ability to work independently as well as collaboratively in an interdisciplinary environment
- High motivation and enthusiasm for research
- Experience with 3D cell culture or tissue models (desirable)
- Knowledge of host–pathogen interactions or infection models (desirable)
- Familiarity with biofabrication, hydrogels, or biomaterials (desirable)
- Exposure to advanced imaging or omics approaches (desirable)
Benefits
- An interesting and varied job in an exciting and innovative organization
- The opportunity to be part of a highly committed international team
- Modern infrastructure
- High degree of flexibility regarding working hours and location (depending on operational requirements)
- Generous package of social benefits, including supplementary vacation days and pension scheme contributions
- Internal skills training opportunities and support for continued education
Bist du Teil dieses Unternehmens?
Dieses Unternehmensprofil wurde automatisch erstellt. Wenn du für AO Foundation arbeitest, kannst du das Profil jetzt beanspruchen und verifizieren – kostenlos und in wenigen Minuten.
Über uns
Das Team
Be part of a highly committed international team with people from diverse backgrounds and specialist areas, united by a passion for excellence and dedication to improving patient care.